Coffee protects against cardiovascular diseases - this has already been confirmed 0
Coffee protects against cardiovascular diseases - this has already been confirmed

Scientists at McMaster University have discovered how caffeine protects against cardiovascular disease. For the first time, it was possible to confirm this experimentally.

Just 2-3 medium-sized cups of coffee a day contain enough caffeine to induce a cascading effect that lowers low-density lipoprotein (LDL), or "bad" cholesterol. High levels of LDL in the bloodstream are associated with an increased risk of cardiovascular disease.

- Drinkers of coffee and tea have another important health reason to be happy. Our findings indicate a fundamental mechanism by which caffeine and its derivatives can reduce blood levels of PCSK9 and thus reduce the risk of cardiovascular disease, said Prof. Richard Austin of McMaster University, lead author of the study.

Caffeine and its derivatives block the activation of the SREBP2 protein, which reduces the level of PCSK9 protein in the blood, thereby increasing the liver's ability to remove excess LDL cholesterol from the bloodstream.

- Given that SREBP2 is involved in many cardiometabolic diseases such as diabetes and fatty liver disease, easing its effects has far-reaching implications - added Prof. Austin.

This molecular domino effect is similar to another phenomenon previously described by Prof. Austin. In 2020, scientists discovered how a rare mutation in the PCSK9 gene reduces the release of protein from the liver, lowers cholesterol levels, and prolongs life in people who carry it.

These findings have broad implications as they link a commonly consumed, biologically active relationship to cholesterol metabolism at the molecular level. This discovery was completely unexpected and shows that ordinary food and drinks have a much more complex effect than we think - added Prof. Guillaume Paré, co-author of the study.

Scientists have developed new caffeine derivatives that strongly lower blood levels of PCSK9, potentially leading to new approaches to lowering LDL cholesterol.

- We are excited about the fact that we are working on a new class of drugs - nutraceuticals - for the potential treatment and prevention of cardiovascular diseases - concluded Prof. Jakob of McMaster University, one of the authors of the discovery.

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